How To Unlock Slay The Spire 2 Epochs

Progression in Slay The Spire 2 relies on you completing objectives in your countless runs. You can keep track of what you've unlocked via the Timeline, a series of events that expand on the story, as well as give objectives for you to complete. By finishing them, you'll get rewards that will then begin appearing in future runs, such as single-use potions, perk-giving relics, and busted cards.

Some of the requirements are your typical Roguelike game fare: playing through runs until your inevitable demise. However, others need you to beat some of the tricky Slay The Spire 2 bosses, kill several elite enemies, or reach a predetermined point value across all of your runs. There are so many objectives in the first version of Slay The Spire 2's early access, including some that hint at new areas and unlockables that will appear in the future, so let's go through all the Epochs and what they unlock.

The Timeline shows all previously unlocked Epochs, while conditions for unlocking characters, modes, relics, cards, and potions are hidden behind blurred images.

All Slay The Spire Timeline Epoch unlock conditions​

There are currently over 50 Slay The Spire 2 Epochs you can unlock in the early access period across your many runs. It will likely take you dozens of runs to complete the entire Timeline, and more are sure to follow over the next few months. Rather than having to flip back and forth to see what the objectives are, here are all the unlock conditions for the Epochs in one place:

Epoch	Unlocks	Unlock Condition
Preon	Automation, Catastrophe, and Entropy cards	Accumulate score.
Magnum Opus	Reptile Trinket, Unsettling Lamp, and Intimidating Helmet relics	Accumulate score.
The Architect	Prep Time, Eternal Armor, and Jackpot cards	Accumulate score.
Nemesis	Snecko Skull, Twisted Funnel, and Helical Dart relics	Kill 15 bosses with the Silent.
Seeds	Custom (game mode)	Beat Act 3 three times.
Ancients	Book of Five Rings, Kusarigama, and Ice Cream relics	Accumulate score.
Traitors	Prowess, Rend, and Beat Down cards	Accumulate score.
The Pact	Blood Potion, Ashwater, and Soldier's Stew potions	Beat Act 3 with the Ironclad.
Devastation	Red Skull, Paper Phrog, and Ruined Helmet relics	Beat Act 2 with the Ironclad.
Somewhere	Unlockable is unknown at this time.	Accumulate score.
Elsewhere	Unlockable is unknown at this time.	Accumulate score.
The Ironclad	Molten Fist, Dominate, and Cruelty cards	Beat Act 1 with the Ironclad.
Trophies	Poison Potion, Cunning Potion, and Ghost in a Jar potions	Beat Act 3 with the Silent.
Poisoner	Reflex, Hand Trick, and Master Planner cards	Kill 15 elites with the Silent.
Laser Beams	Gold-Plated Cables, Emotion Chip, and Power Cell relics	Kill 15 bosses with the Defect.
Ablaze	Cinder, Drum of Battle, and Pact's End cards	Kill 15 elites with the Ironclad
The Calm	Powdered Demise, Touch of Insanity, and Ship in a Bottle potions	Accumulate score.
Bigger Prey	Snakebite, Bubble Bubble, and Accelerant cards	Beat Act 1 with the Silent.
Orobas	Orobas (Ancient)	Played a run with every character.
Discontent	Regalite, Mini Regent, and Orange Dough relics	Kill 15 bosses with the Regent.
Hello! Hello!	Data Disk, Symbiotic Virus, and Metronome relics	Beat Act 2 with the Defect.
Civilization	Festive Popper, Ripple Basin, and Vexin Puzzlebox relics	Accumulate score.
Resolving Bugs	Focus Potion, Potion of Capacity, and Essence of Darkness potions	Beat Act 3 with the Defect.
Anomalous Planet	Regent (Character)	Played a run with the Silent.
Ill	Tingsha, Tough Bandages, and Paper Krane relics	Beat Act 2 with the Silent.
Snuffed	Self-Forming Clay, Charon's Ashes, and Demon Tongue relics	Kill 15 bosses with the Ironclad.
Friends	BEGONE!, Supermassive, and Arsenal cards	Kill 15 elites with the Regent.
Confrontation	Barrage, Smokestack, and Flak Cannon cards	Kill 15 elites with the Defect.
Open	Beetle Juice, Mazaleth's Gift, and Droplet of Precognition potions	Accumulate score.
Neow	Neow (Ancient)	Complete your first run.
The Twelve	Scourge, Countdown, and Oblivion cards.	Beat Act 1 with the Necrobinder.
Fog Rolls In	Silent (Character)	Played a run as the Ironclad.
I Arrive	Spoils of Battle, Furnace, and Sword Sage cards	Beat Act 1 as the Regent.
Booting Up	Defect (Character)	Played a run with the Necrobinder.
Futility	Bone Flute, Funeary Mask, and Book Repair Knife relics	Beat Act 2 as the Necrobinder.
Underdocks	Underdocks (Alternate Act 1)	Accumulate score.
We need a Hero!	Fencing Manual, Galactic Dust, and Lunar Pasty relics	Beat Act 2 with the Regent.
Tricked	Loop, Null, and Consuming Shadow cards	Beat Act 1 with the Defect.
Spireborn	Potion of Doom, Bone Brew, and Pot of Ghouls potions	Beat Act 3 with the Necrobinder.
Grand Strategy	Star Potion, King's Courage, and Cosmic Concoction potions	Beat Act 3 with the Regent.
The Giant	Afterlife, Calcify, and Sacrifice cards	Kill 15 elites with the Necrobinder.
Annihilation	Ivory Tile, Big Hat, and Bookmark relics	Kill 15 bosses with the Necrobinder.
Darv	N/A	Encounter all other Ancients.
Life and Death	Necrobinder (Character)	Played a run with the Regent.
Little King	Patter, Lunar Blast, and Heavenly Drill cards	Beat Ascension 1 with the Regent.
My Face	Blood Wall, Inferno, and Tear Asunder cards	Beat Ascension 1 with the Ironclad.
Soup	Hidden Daggers, Phantom Blades, and Blade of Ink cards	Beat Ascension 1 with the Silent.
The Daily	Daily (Game mode)	Play a single run with all characters and beat Act 3.
Ooh Shiny!	TURBO, Scavenge, and Helix Drill cards	Beat Ascension 1 with the Defect.
To Kill	Sculpting Strike, Veilpiercer, and Banshee's Cry cards	Beat Ascension 1 with the Necrobinder.
Slumber	Alchemize, Nostalgia, and Scrawl cards	Accumulate score.
Consequences	Miniature Cannon, Tungsten Rod, and White Star relics	Accumulate score.
Buy Something!	Splash, Anointed, and Calamity cards	Accumulate score.
The Spire	Colorful Philosophers (event)	Accumulate score.
Arise	Tiny Mailbox, Joss Paper, and Beating Remnant relics	Accumulate score.
Cultists	Trash Heap (event)	Accumulate score.
They Return	N/A	Accumulate score.

Source